Multiple strategies for safer conception need to incorporate couples' preferences

Lesley Odendal
Published: 03 July 2015

Misunderstandings about serodiscordance and limited understanding of female fertility and male insemination are barriers to couples in serodiscordant partnerships in attempting to practice safer conception methods, according to a qualitative study presented by Rebecca Phofa at the 7th South African AIDS Conference in Durban last month.

Safer conception preferences were largely influenced by an assessment of the effectiveness of the intervention at reducing or eliminating risk, concerns over side-effects of antiretroviral treatment (ART) and knowledge about the method.

Safer conception services are needed to reduce both horizontal and vertical transmission risks among serodiscordant couples trying to become pregnant. Several strategies exist to address this, including early initiation of ART for HIV-positive partners, independent of CD4 count, with viral load monitoring to confirm viral load suppression; pre-exposure prophylaxis (PrEP) for HIV-negative partners; condomless sex limited to the peri-ovulation period; or manual self-insemination using a plastic syringe if the male partner is HIV-negative.

In-depth interviews and focus groups were held in English, Zulu and Sotho and facilitated by trained researchers using semi-structured interview guides between February and July 2013 with women and men who were in a relationship with an HIV-positive partner and were hoping to have a child in the near future.

Barriers to acceptability of PrEP for HIV-negative individuals were driven by concerns about side-effects and duration.

“People taking ARVs are only doing it because they are sick. Most fear the side effects these ARVs come with,” said a woman with HIV. “I don’t like pills because of side-effects…The syringe would be easier than taking pills every day,” said an HIV-negative man. “She must go for ARVs in the time when she tries to conceive or forever? [If just while she tries to conceive] then she could do this,” said a man with HIV.

Acceptability of manual insemination differs between HIV-positive and HIV-negative men.

“Men don’t want to be robbed of our manhood. It’s not going to be our baby, it is like it’s someone else’s [if manual insemination is used],” said a man with HIV, while an HIV-negative man stated, “I would use the syringe as long as I would get a baby and I wouldn’t get the virus. The most important thing is to have a baby and remain HIV-negative. How the baby is done is not important.”

Misunderstandings about serodiscordance were also iterated. “The child might get infected, because even though I’m [HIV-]negative, I don’t think I’m 100% negative. If I sleep with someone who is negative, I might infect that person,” stated an HIV-negative woman.

There is also a limited understanding of female fertility and male insemination, as displayed in the responses below:

“Is there a certain temperature that semen need to be to live? Because it might cool down too much before I put it in.”

“Does she need to be hot or in the mood?”

“When there is penetration, you are closer to the cervix. But how will they [semen] get there?”

Based on the study, Phofa advocated that “effective safer conception services require a strong counselling component and a comprehensive approach with multiple strategies offered to incorporate patient preference, rather than a single algorithm.”


Phofa R et al. Acceptability and preference for antiretroviral and non-antiretroviral-based HIV prevention strategies for safer conception. 7th South African AIDS Conference, June 2015, Durban, South Africa.

Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.