Lipid peroxidation

Lipid peroxidation is another mechanism through which cardiovascular disease is thought to develop. Paraoxonase-1 (PON1) is an enzyme that preserves HDL and LDL cholesterol from peroxidation, and hence may possibly be protective against atherosclerosis.

Studies have produced conflicting results regarding the relationship between variations in the gene that expresses paraoxonase and the risk of cardiovascular disease, despite evidence from mouse models that the presence or absence of the gene in mice is associated with the risk of atherosclerosis. In a case-control study of patients with lipodystrophy, metabolic disorders, a positive cardiovascular risk or atherosclerosis compared to HIV-positive patients without any of these conditions, the H7 haplotype of PON1 was associated with greater increases in CD4 cell count, higher levels of HDL cholesterol and apolipoprotein A1, lower triglyceride levels and lower rates of subclinical arteriosclerosis.1


  1. Parra S et al. Paraoxanase-1 gene haplotypes are associated with metabolic disturbances, atherosclerosis and immunologic outcome in HIV-infected patients. J Infect Dis 201: 627-634, 2010
Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.